Notch inhibition with GSIs did not alter the DNA damage response of glioma stem cells following radiation, but rather impaired radiation-induced Akt activation and upregulated levels of the truncated apoptotic isoform of Mcl-1 (Mcl-1s). Taken together, our results suggest a critical role of Notch to promote radioresistance of glioma stem cells.

It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was …

cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18. PMID 17051156 : Anaplastic oligodendroglioma. Blakeley J, Grossman S. Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation.

cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). Thus, tumours sur- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines.

Blakeley J, Grossman S. Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease.

brain tumors select for and induce a more stem-like population of cells that can activation of the DNA damage response. The CD133+ Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

2006;444:756–60. Google Scholar | Crossref | Bao, S., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature.

View 0 peer reviews of Glioma stem cells promote radioresistance by preferential activation of the DNA damage response on Publons Download Web of Science™ My Research Assistant : Bring the power of the Web of Science to your mobile device, wherever inspiration strikes.

Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that short-term cultures of glioma xenografts subjected to three serial cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. Download Citation | On Jan 1, 2008, R.J. Arceci published Glioma stem cells promote radioresistance by preferential activation of the DNA damage response | Find, read and cite all the research you The mechanisms underlying tumour radioresistance have remained elusive.

Strategies depending on targeting DNA damage response network in gliomas were applied to sensitize tumors and reverse radioresistance [16, 17]. In this article, Singh and colleagues undertook a comparative evaluation of pre-clinical efficacy and safety of three immunotherapeutic modalities directed against CD133 braintumor-initiating cells. While all three modalities were efficacious in orthotopic GBM xenografts, CD133-specific CAR-T cells represented the most therapeutically tractable strategy against functionally important CD133 Bao S, Wu Q, McLendon RE, et al.
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The CD133+ Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756–60. Google Scholar | Crossref | 7 Dec 2006 Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response 28 Jul 2010 Neural Stem Cells through Recruitment of the DNA Damage BMI1 deficiency in GBM cells severely impaired DNA DSB response, resulting in increased sensitivity to iments, that CD133 cells preferentially activate the DN 8 Apr 2013 ATR functions in response to endogenous DNA damage; however, Glioma stem cells promote radioresistance by preferential activation of 23 Oct 2014 (38) Along this line, CHK1 is activated in response to DNA damage, Glioma stem cells promote radioresistance by preferential activation of 27 Apr 2014 radio-resistance in glioblastoma by regulating DNA repair and cell differentiation The stem-like state and preferential activation of DNA damage response in the GBM tumor-initiating cells contribute to their radio- 25 May 2020 Dr. Jason Hamlin discusses the role of brain tumor stem cells in the development of glioblastoma treatment resistance.

2019-02-05 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp.
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2017-10-09 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444 : 756–760. CAS Article Google Scholar

The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas.

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Autores: Shideng Bao, Qing Shi, Yueling Hao, Roger E. McLendon, Darell D. Bigner, Qiulian Wu, Anita B. Hjelmeland, Jeremy N. Rich, Mark W. Dewhirst

Neoplastic Stem Cells Subject Areas on Research 4-Hydroperoxycyclophosphamide purging of breast cancer from the mononuclear cell fraction of bone marrow in patients receiving high-dose chemotherapy and autologous marrow support: a phase I trial. McLendon et al., "Glioma stem cells promote radioresistance by preferential activation of the DNA damage response," Nature, vol. The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer 2006-10-18 · The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.

Download Citation | On Jan 1, 2008, R.J. Arceci published Glioma stem cells promote radioresistance by preferential activation of the DNA damage response | Find, read and cite all the research you

McLendon et al., "Glioma stem cells promote radioresistance by preferential activation of the DNA damage response," Nature, vol. The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer 2006-10-18 · The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas.

Google Scholar | Crossref | Bao, S., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 444, 756-760 (2006).